EXTRACT ETHANOL SEAWEEDS LOWERING LEVEL OF SERUM HMG-CoA REDUCTASE ENZYME OF WISTAR RATS HYPERCHOLESTEROLEMIA

Ketut Sri Marhaeni , Julyasih (2012) EXTRACT ETHANOL SEAWEEDS LOWERING LEVEL OF SERUM HMG-CoA REDUCTASE ENZYME OF WISTAR RATS HYPERCHOLESTEROLEMIA. International Journal of Biosciences and Biotechnology , 1 (1). pp. 32-34. ISSN 9 772302 257 000

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Abstract

Hypercholesterolemia or hyperlipidemia has been established as an important risk factor of cardiovascular disease. Patients with hypercholesterolemia usually require a prolonged treatment; and the newer and more potent generation of antilipid agents is costly In Bali there are several types of seaweed that are generally consumed by local people and known by local names of Bulung Boni (Caulerpa spp.) and Bulung Sangu (Gracilaria spp.). Effect of Bulung Boni and Bulung Sangu extracts to reduce level of HMG-CoA reductase enzyme are still very limited both in extent and depth, and further investigations were considered relevant and needed. This experimental study used completely randomized design, using a total of 24 Wistar rats divided into six sample groups of equal size, all fed with a diet high in cholesterol content. The six sample groups were respectively designated as negative control group, positive control group, and four treated sample groups, respectively, fed orally with a dose of 20 mg and 60 mg extracts of Bulung Boni per 100g of body weight per day, and 20 mg and 60 mg extracts of Bulung Sangu per 100g body weight per day. Each treatment was repeated four times. Results showed that rats fed with high-cholesterol diet and treated with oral Bulung Boni or Bulung Sangu extract at a dose of 20 mg and 60 mg/100 g bw/ day were statistically significantly decrease serum HMG-CoA reductase enzyme levels (p < 0.05) as compared with those of rats fed with high cholesterol diet without treatment with Bulung Boni or Bulung Sangu extracts. It implied that Bulung Boni and Bulung Sangu extracts decrease level of HMG-CoA reductase enzyme by significantly lowering serum HMG-CoA reductase enzyme levels.

Item Type: Article
Subjects: S Agriculture > SB Plant culture > SB950 Pests Control
Divisions: UNSPECIFIED
Depositing User: Users 2 not found.
Date Deposited: 19 Oct 2012 12:32
Last Modified: 19 Oct 2012 12:32
URI: http://eprints.upnjatim.ac.id/id/eprint/3944

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